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KMID : 0603519990040030165
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Journal of Korean Association of Cancer Prevention
1999 Volume.4 No. 3 p.165 ~ p.165
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The Cancer-preventive Potential of Panax Ginseng: A Review of Human and Experiment Evidence
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Abstract
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Objective : We have reviewed the potential cancer and other relevant properties of Panax ginseng C. A. Meyer, which has been traditionally used as natural tonics in oriental countries.
Method and materials : publications on Panax Ginseng and its relation to cancer,carcinogenicity and anticarcinogenicity were searched from Medline database (1983-1998) and by checking reference lists to find earlier reports. The reports also cover experimental models on cancer-preventive activity, carcinogenicity and other beneficial or adverse effects. In addition, possible mechanisms of chemoprevention by ginseng were also considered.
Results : Recently published results from a cohort and two case-control studies in Korea suggest that the intake of ginseng may reduce the risk of several types of cancer. When ginseng was tested in animal models, a reduction in cancer incidence and multiplicity at various sites was noted Panax Ginseng and its chemical constituents have been tested for their inhibiting effect on putative carcinogenesis mechanisms (e.g., cell proliferation and apoptosis, immunosurveillance, angiogenesis); in most experiments inhibitory effects were found.
Conclusion : While Panax Ginseng C.A. Meyer has shown cancer preventive effects both in experimental models and in epidemiological studies, the evidence if currently not conclusive as to its cancer-preventive activity in humans. The available evidence warrants further research into the possible role of ginseng in the prevention of human cancer and cacinogenesis.
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KEYWORD
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Panax ginseng, Chemoprevention, Anticarcinogenesis
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